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Anti-SOST Antibody Fab (CAT#: MOM-18116-F(E))

Datasheet
DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human SOST Antibody Fab Fragment MOM-18116-F(E) 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Humanized (from mouse) Antibody Fab Fragment specifically binds to Human SOST, expressed in Chinese Hamster Ovary cells(CHO)
  • Target
  • SOST
  • Type
  • Fab Fragment based on Humanized (from mouse) IgG2 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
  • Specific Activity
  • Tested positive against native antigen.
  • Predicted N terminal
  • H chain: EVQLVQS; L Chain: DIQMTQS
  • Purity
  • >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
  • Storage
  • 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

BACKGROUND

  • Antigen Description
  • Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antaggedonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
  • Function
  • heparin binding; protein binding; transcription factor binding;
  • Synonyms
  • SOST; sclerostin; sclerosteosis; VBCH;

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